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Office Rooms: 103/109, Cummings Life Science Center
Lab: MRIS Annex, located at the junction of the Abbott/CLSC/Crerar tunnels
Lab Phone: (773) 702-4057
FAX: (773) 834-3193

The MRIS Facility is the beneficiary of funding support from the University of Chicago Cancer Research Center.

Dr. Gregory Karczmar

Co-leader of the

Advanced Imaging Program

Dr. Brian Roman

Director of Molecular &

Physiological Imaging

Welcome message from the Faculty Co-Directors:


The 9.4T/30cm MRI Facility was created as part of the basic sciences research within the Department of Radiology.  Our goal is to advance state of the art animal imaging technology at the anatomic and functional level.  Our research also serves as a resource for the development of clinical imaging techniques in the diagnostic medical field.  The goal of the Consortium is to facilitate inter-institutional collaboration between Academic Institutions within University of Chicago and Medical Center that can transfer this technology to the clinical area and the public.

Best Wishes!

News update:  Last time edited: 11/11/2009

  • November 11, 2009 - There were total of six abstracts from this lab submitted for the ISMRM 18th Scientific Meeting which will be held in 2010 Stockholm, Sweden.

  • October 30, 2009 - Dr. Sanaz (Sunny) Jansen and her colleagues published the following article in Radiology:
    Jansen SA, Paunesku T, Fan X, Woloschak GE, Vogt S, Conzen SD, Krausz T, Newstead GM, Karczmar GS.  Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.  Radiology. 2009 Nov;253(2):399-406.

  • October 20, 2009 - Dr. Sanaz (Sunny) Jansen and her colleagues published the following article in Academic Radiology:
    Jansen SA, Fan X, Yang C, Shimauchi A, Karczmar G, Newstead GM.  Relating Dose of Contrast Media Administered to Uptake and Washout of Malignant Lesions on DCEMRI of the Breast(1).  Acad Radiol. 2009 Oct 14.

  • September 28, 2009 - A big congratulations to Mr. Martin Andrews and Mr. Federico Pineda on passing their Ph.D. qualifying exam on September 18.  Mr. Andrews and Mr. Pineda will be working towards their Ph.D. under the guidance of Prof. Roman and Prof. Karczmar, respectively.  We welcome both to the lab and wish for their success!

  • September 24, 2009 - Congratulations to Drs. Kathy Millen and Brian Roman for receiving funds from ARRA (American Recovery and Reinvestment Act) as part of the IDDRC (Intellectual and Developmental Disabilities Research Center).  This will help buy a license for Amira and a mouse head holder for MRI experiments.

  • September 21, 2009 - We are pleased to congratulate Ms. Anita Dhyani on passing her Ph.D. qualifying exam last Friday.  She will be working towards her Ph.D. under the guidance of Prof. Roman.  Welcome to the lab!

  • September 20, 2009 - Dr. Sanaz (Sunny) Jansen is going to leave us at the end of this month.  She is taking a prestigious position as a post-doctoral scholar at the NCI (National Cancer Institute).  We will miss her and wish her good luck and much happiness!

  • September 11, 2009 - Dr. Milica Medved and her colleagues published the following article in Physics in Medicine and Biology:
    Medved M, Newstead GM, Fan X, Du YP, Olopade OI, Shimauchi A, Zamora MA, Karczmar GS.  Fourier component imaging of water resonance in the human breast provides markers for malignancy.  Phys Med Biol. 2009 Sep 9;54(19):5767-5779.

  • Septemper 8, 2009 - Dr. Sanaz (Sunny) Jansen and her colleagues published the following article in Breast Cancer Research:
    Jansen SA, Conzen SD, Fan X, Markiewicz EJ, Newstead GM, Karczmar GS.  Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.  Breast Cancer Res. 2009 Sep 4;11(5):R65.

  • September 2, 2009 - We are pleased to announce that we have installed a new gradient insert in the 9.4T magnet during the month of August.  This new Bruker BGA12-S gradient set, with an inner diameter of 116 mm, has a built-in shim set which allows for better signal to noise ratio at higher resolution imaging with increased shim strengths.  These BGA12-S improves our small animal imaging capabilities with higher gradient strengths (660 mT/m), significantly better shimming, and optimal gradient linearity - for the complete list of technical specifications, please see the following Bruker website:  http://www.bruker-biospin.com/mri_gradients.html

  • August 24, 2009 - Dr. Sanaz (Sunny) Jansen and her colleagues published the following article in American Journal of Roentgenology:
    Jansen SA, Shimauchi A, Zak L, Fan X, Wood AM, Karczmar GS, Newstead GM.  Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.  AJR Am J Roentgenol. 2009 Sep;193(3):832-9.

  • August 13, 2009 - Congratulations Ms. Abbie Wood for receiving an NIH fellowship award to promote diversity in health related research.  The funding will support her during her remaining time as a graduate student and her first year as a post-doctoral scholar.

  • August 4, 2009 - Dr. Xiaobing Fan and his colleagues published the following article in Physica Medica:
    Fan X, Mustafi D, Zamora M, River JN, Foxley S, Karczmar GS.  Can DCEMRI assess the effect of green tea on the angiogenic properties of rodent prostate tumors?  Phys Med. 2009 Jul 31.

  • July 27, 2009 - Dr. Milica Medved and her colleagues published the following article in Magnetic Resonance Imaging:
    Medved M, Newstead GM, Abe H, Olopade OI, Shimauchi A, Zamora MA, Karczmar GS.  Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage.  Magn Reson Imaging. 2009 Jul 21.

  • July 16, 2009 - We are pleased to inform you that Ms. Marieke Heisen, Ms. Abbie Wood, Mr. Jonathan River, and Drs. Chad Haney, Sanaz (Sunny) Jansen, and Devkumar Mustafi had their abstracts accepted for Oral Presentation at 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), November 29 – December 4, in Chicago, Illinois:2009 World Molecular Imaging Congress (WMIC):
    (1) Heisen M, Wood AM, Buurman J, Mustafi D, Peng E, Yang C, Ivancevic MK, Newstead GM, Karczmar GS.  Standardization and Calibration for Breast MRI: The Use of a Unique Air Bubble Free Agar Phantom.

    (2) Heisen M, Fan X, Buurman J, Ter Haar Romeny BM.  The Effect of the Temporal Resolution of the Arterial Input Function (AIF) on Pharmacokinetic Parameter Estimation from Dynamic Contrast-enhanced (DCE) MRI Data.

    (3) Wood AM, Medved M, Foxley S, Bacchus I, Olopade OI, Shimauchi A, Swaminathan S, Newstead GM, Karczmar GS.  High Resolution Images of Non-Lorentzian Components of the Water Resonance Detect Blood Vessels and May Be Used to Distinguish Malignant from Benign Breast Lesions: A Pilot Study.

    (4) Foxley S, Fan X, River J, Zamora M, Markiewicz E, Sokka S, Karczmar G.  Mild Hyperthermia Produces Significant Contrast Changes in High Spectral and Spatial Resolution (HiSS) MR Images of PC3 Tumors.
    (5) Haney CR, Fan X, Zamora M, Markiewicz E, Karczmar GS, Mauceri HJ, Pelizzari CA, Weichselbaum RR.  Dynamic-Contrast-Enhanced-MRI shows radiation resistant tumor (Nu61) is also resistant to TNFα treatment.
    (6) Jansen SA, Conzen S, Fan X, Markiewicz E, Newstead GM, Karczmar GS.  Insights into Early Breast Cancer Detection and Progression Using Magnetic Resonance Imaging of Transgenic Mice.
    (7) Mustafi D, Fan X, Dougherty U, Bissonnette M, Karczmar GS, Markiewicz E, Zamora M.  High-resolution Magnetic Resonance Colonography and Dynamic Contrast-enhanced Magnetic Resonance Imaging Can Distinguish Early Murine Colorectal Tumors from Colitis in vivo.

  • July 6, 2009 - Dr. Devkumar Mustafi and his colleagues published the following article in the Journal of Biological Inorganic Chemistry:
    Mustafi D, Peng B, Foxley S, Makinen MW, Karczmar GS, Zamora M, Ejnik J, Martin H.  New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer.  J Biol Inorg Chem. 2009 Jul 2.

  • July 1, 2009 - Dr. Lara Leoni and her colleagues had the following abstract accepted for Oral Presentation for the 2009 World Molecular Imaging Congress (WMIC):
    Lara Leoni, Anita Dhyani, Patrick LaRiviere, Brian B. Roman.  b-cell Sub-cellular Localization of Glucose Stimulated Mn Uptake By X-ray Fluorescence: Implications for Pancreatic MRI.  September 23-26, 2009.  Montreal, Canada.

  • June 2, 2009 - We are pleased to inform you that Dr. Xiaobing Fan serves as a member of the Publications Committee for the International Society for Magnetic Resonance in Medicine (ISMRM).

  • May 19, 2009 - Dr. Chad Haney and his colleagues published the following article in Magnetic Resonance in Medicine:
    Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, Pelizzari CA.  Characterization of response to radiation mediated gene therapy by means of multimodality imaging.  Magn Reson Med. 2009 May 15;62(2):348-356.

  • May 18, 2009 - Drs. Xiaobing Fan and Gregory Karczmar published the following article in Magnetic Resonance in Medicine:
    Fan X, Karczmar GS.  A new approach to analysis of the impulse response function (IRF) in dynamic contrast-enhanced MRI (DCEMRI): A simulation study.  Magn Reson Med. 2009 May 15;62(1):229-239.

  • April 16, 2009 - We submitted a total of 12 abstracts to RSNA (Radiological Society of North America) this year covering both pre- and clinical research.

  • Mar. 5, 2009 - Congratulations to Dr. Brian Roman for receiving funding in the amount of $545K from his Seeding Collaborative Research in Beta Cell Biology (SCRBCB) application to the Beta Cell Biology Consortium entitled "Non-invasive Imaging of Beta Cell Graft Function, Vascularization and Perfusion'.

  • Feb. 3, 2009 - Dr. Cheng Yang and his colleagues published the following article in Magnetic Resonance in Medicine:
    Yang C, Karczmar GS, Medved M, Oto A, Zamora M, Stadler WM. 
    Reproducibility assessment of a multiple reference tissue method for quantitative dynamic contrast enhanced-MRI analysis.  Magn Reson Med. 2009 Apr;61(4):851-9.

  • Feb. 2, 2009 - Under the leadership of Drs. Karczmar and Roman, we have a total of 15 abstracts that have been selected for presentation at the scientific sessions of the ISMRM 2009 Annual Meeting in Honolulu, Hawai’i, USA.  Out of 15 abstracts, one abstract from Dr. Sanaz (Sunny) Jansen have been accepted as oral presentation:
    Sanaz A. Jansen, Suzanne D. Conzen, Xiaobing Fan, Erica Markiewicz, Gillian Newstead and Gregory S. Karczmar. "Magnetic resonance imaging reveals the progression, regression and indolence of in situ carcinoma
    in transgenic mice."

  • Jan. 26, 2009 - Dr. Sean Foxley and his colleagues published the following article in Magnetic Resonance in Medicine:
    Foxley S, Fan X, Mustafi D, Haney C, Zamora M, Markiewicz E, Medved M, Wood AM, Karczmar GS.  Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images.
      Magn Reson Med. 2009 Jan 22;61(2):291-298.

  • Jan. 23, 2009 - Congratulations to Dr. Brian Roman for becoming co-chair of IACUC (institutional animal care and use committee).

 

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